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Exo

Exosomes – A New Frontier in Regenerative Medicine

Exosomes are extracellular micro-vesicles (30-150nm) that are involved in direct cell to cell communication. Direct Biologics’ ExoFlo™ exosomes are isolated from human bone marrow mesenchymal stem/ stromal cells (MSCs). They are purified using proprietary cGMP processing and are sterile filtered and tested per USP<71> sterility testing. The unique benefit to Direct Biologics exosomes is they provide a wide array of regulatory proteins to stimulate and modulate many processes within the normal healing cascade.

Exosomes are not cells. Exosomes are tiny lipid vesicles that are secreted from a cell and are about 1/1,000th the size of a cell.


Exovid

The Science of Exosomes


Exosomes are regarded as the purest form of cellular signaling available because their function is to direct tissue and wound healing by activating cell responses. This is the newest generation of naturally bioactive products for regenerative therapies.

The exosomes in ExoFlo are paracrine signals that assist with local cell-to-cell communication. Exosomes induce changes in nearby cells that create the appropriate healing environment and aid in tissue repair. As the technology and discovery of new methods of treating patients has evolved, scientific evidence shows that the optimal way to provide true regenerative therapy is to directly provide the signals as its own therapy and avoid potential issues with delivering and keeping transplanted cells alive.1,2

Stem and progenitor cells by nature work to heal, repair, and restore the body. But, in some cases where there is a chronic abnormality, these cells are inhibited by an inflammatory state, work in an unregulated capacity and fail to replace lost cells. The 1,000+ regulatory proteins, RNAs and other biomolecules found to naturally occur in healthy tissue and in ExoFlo have been shown preclinically to help modulate inflammatory healing processes.2 This is accomplished by activating and recruiting local cells to revascularize the area and reduce the inflammatory response to allow natural healing.


*Procedure performed by licensed medical professional 


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